Gene Therapy

Research from University of Rome, Department of Biology in the area of gene therapy published

Published in Cancer Weekly, May 22nd, 2007

A report, "Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation," is newly published data in Endocrine-related Cancer. "The cellular functions regulated by 17beta-estradiol (E2) start after the hormone binds to its receptors (i.e., ERalpha and ERbeta). These act as ligand-dependent transcription factor transactivating target genes," researchers in Roma, Italy report.

"In addition, E2 induces non-genomic actions, whose activation is triggered by a fraction of the ERs localized at the plasma membrane. Palmitoylation allows ERalpha to localize at the plasma membrane, to associate with caveolin-1, and, upon E2 stimulation, to...

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Source: Cancer Weekly (2007-05-22)

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