Acute Lymphoblastic Leukemia Genetics
Studies in the area of acute lymphoblastic leukemia genetics reported from Aichi Cancer Center Research Institute, Division of Molecular Medicine
Published in Cancer Weekly, May 29th, 2007
Fresh data on acute lymphoblastic leukemia are presented in the report "Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblastic leukemia: analysis by means of array-based comparative genomic hybridization. The TEL (ETV6)-AML1 (RUNX1) chimeric gene fusion is the most common genetic abnormality in childhood acute lymphoblastic leukemias. Evidence suggests that this chimeric gene fusion constitutes an initiating mutation that is necessary but insufficient for the development of leukemia," scientists in Nagoya, Japan report.
"In a search for additional genetic events that could be linked to the development of leukemia, we applied a genome-wide...
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Source: Cancer Weekly (2007-05-29)
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