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New cancer study findings have been published by scientists at University of Maryland, Marlene and Stewart Greenebaum Cancer Center

Published in Cancer Weekly, May 29th, 2007

Research findings, "Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism," are discussed in a new report. According to recent research published in the British Journal of Cancer, "The pentacyclic acridinium methosulfate salt RHPS4 induces the 3'single-stranded guanine-rich telomeric overhang to fold into a G-quadruplex structure. Stabilisation of the latter is incompatible with an attachment of telomerase to the telomere and thus G-quadruplex ligands can effectively inhibit both the catalytic and capping functions of telomerase."

"In this study, we...

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