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Cancer Gene Therapy

New findings reported from Cancer Institute describe advances in cancer gene therapy

Published in Cancer Weekly, May 29th, 2007

Scientists discuss in "Poorly differentiated and anaplastic thyroid carcinomas: chromosomal and oligo-array profile of five new cell lines" new findings in cancer gene therapy. "Information on gene alterations associated to poorly differentiated (PDTC) and anaplastic thyroid carcinomas (ATC) is scarce. Using human cancer cell lines as a tool for gene discovery, we performed a cytogenetic and oligo-array analysis in five new cell lines derived from two PDTC and three ATC," investigators in Lisbon, Portugal report.

"In PDTC we evidenced, as important, the involvement of the MAPK/ERK kinase pathway, and downregulation of a group of suppressor genes that include E-cadherin....

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