Breast Cancer Cell Biology
Researchers at Duke University, Department of Surgery target breast cancer cell biology
Published in Cancer Weekly, June 5th, 2007
Research findings, "Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells," are discussed in a new report. According to recent research published in the journal Cancer Research, "Osteopontin is a glycoprotein that has been linked to metastatic function in breast, lung, and prostate cancers. However, the mechanism by which osteopontin acts to induce metastatic properties is largely unknown."
"One intriguing feature of osteopontin is the presence of a conserved thrombin cleavage site that is COOH-terminal from a well-characterized RGD domain. Although the COOH-terminal fragment may bind to cell surface...
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Source: Cancer Weekly (2007-06-05)
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