Cancer
Studies from Institute for Cancer Research, Research Department yield new information about cancer
Published in Cancer Weekly, July 3rd, 2007
Data detailed in "Biological activity of 5-aminolevulinic acid and its methyl ester after storage under different conditions" have been presented. According to recent research from Oslo, Norway, "5-Aminolevulinic acid (ALA) is a natural precursor of protoporphyrin IX (PpIX) and heme in cells. Photodynamic therapy (PDT) utilizes a metabolic imbalance in cancer cells, leading to increased PpIX generation from exogenous ALA."
"Due to chemical instability of ALA in therapeutic concentrations at pH values larger than 5.0 and at high temperatures, it looses its activity by spontaneous dimerization to 2,5-dicarboxyethyl-3,6-dihydropyrazine (DHPY). ALA esters are now...
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Source: Cancer Weekly (2007-07-03)
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