Acute Myeloid Leukemia

New acute myeloid leukemia data have been reported by scientists at University of Virginia, Department of Pathology

Published in Cancer Weekly, July 24th, 2007

Current study results from the report, "Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation," have been published. According to a study from the United States, "The leukemic fusion protein AML1-ETO occurs frequently in human acute myeloid leukemia (AML) and has received much attention over the past decade. An initial model for its pathogenetic effects emphasized the conversion of a hematopoietic transcriptional activator, RUNX1 (or AML1), into a leukemogenic repressor which blocked myeloid differentiation at the level of target gene regulation."

"This view has been absorbed into a larger picture of AML1-ETO...

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Source: Cancer Weekly (2007-07-24)

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