Cancer Vaccines

Immune system 'escape hatch' gives cancer cells traction

Published in Cancer Weekly, July 31st, 2007

Scientists at Johns Hopkins and elsewhere say they have mapped out an escape route that cancers use to evade the body’s immune system, allowing the disease to spread unchecked.

In a report published in the July 1 issue of the journal Nature Medicine, the Hopkins team, along with researchers from Florida and Nebraska, describe how myeloid-derived suppressor cells (MDSCs), which normally keep the immune system in check and prevent it from attacking otherwise healthy tissue, can suppress the anti-tumor response to cancer.

These suppressor cells block other immune system cells, CD8 “killer” T cells, from binding with proteins that identify the foreign...

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Source: Cancer Weekly (2007-07-31)

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