Breast Cancer

Reports on breast cancer findings from M. Ciomei and co-researchers provide new insights

Published in Cancer Weekly, August 7th, 2007

"Edotecarin (J-107088, formerly ED-749) is a potent indolocarbazole topoisomerase-I inhibitor that has the potential to treat solid tumors. The current studies evaluated the potency and antitumor activity of edotecarin, as a single agent and in combination with capecitabine or docetaxel," researchers in Nerviano, Italy report.

"Antiproliferative activity was tested in vitro in a panel of 13 mammary cell lines and antitumor efficacy was tested in vivo in various breast cancer models. Results Edotecarin inhibited cellular proliferation in breast carcinoma cell lines: 50% inhibitory concentrations ranged from 8 nmol/L in SKBR-3 cells to similar to 30 mu mol/L in BT20...

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Source: Cancer Weekly (2007-08-07)

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