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Angiogenesis

Studies from University College provide new data on angiogenesis

Published in Cancer Weekly, August 14th, 2007

According to a study from Dublin, Ireland, "The inhibition of angiogenesis, defined as the process of new blood vessel formation, represents a promising strategy for treating cancer. The inhibitory properties of two N-(per-O-acetylated-beta-D-mannopyranosyl)-thiophene-2-carboxamides derivatives (AMTCs, [1],[2]), N(2,3,4,6-tetra-O-ethoxycarbonyl-beta-D-mannopyranosyl)-thiophene2-carboxamide [3] and of 2,3,4,6-tetra-O-acetyl-beta-D-mannopyranosyl-acetamide [4] on the growth of bovine aortic endothelial cells (BAECs) induced by basic fibroblast growth factor (bFGF) were assessed using a [H-3]thymidine incorporation assay. The cellular uptake of AMTCs and the non-acetylated homologue (MTC)...

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