Cancer

Scientists at Vanderbilt University publish new data on cancer

Published in Cancer Weekly, August 14th, 2007

"The present study explores the mechanisms by which human prostatic carcinoma-associated fibroblasts (CAF) induce tumorigenesis in initiated but nonmalignant human prostatic epithelial cells (BPH-1). CAT express elevated levels of both transforming growth factor-beta 1 (TGF-beta 1) and stromal cell-derived factor-1 (SDF-1/CXCL12)," researchers in the United States report.

"TGF-beta inhibits the growth of BPH-1 cells in vitro, but was found to be necessary for the tumorigenic response to CAF. This counterintuitive result suggested that the TGF-beta signaling system was involved in other processes relating to tumorigenesis. The SDF-1 receptor, CXCR4, is expressed at low...

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Source: Cancer Weekly (2007-08-14)

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