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Ganglion

Research from University of Tokyo, Medical Department in the area of ganglion published

Published in Cancer Weekly, August 14th, 2007

According to recent research from Hongo, Japan, "Hypoxia-induced retinal ganglion cell (RCC) death has been implicated in glaucomatous optic neuropathy. However, the precise mechanism of death signaling and how neuroprotective agents affect it are still unclear."

"The aim of this study is to characterize the mechanisms of hypoxia-induced apoptosis of cultured purified RGCs and to study the neuroprotective effects of beta-adrenergic antagonists. Rat RGCs were purified utilizing a modified two-step immuno-parming procedure. First, the extent of apoptosis in RGCs under hypoxia was quantified. Next, the effects of glutamate-channel antagonists (MK801 or DNQX), Bax...

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