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Glioma Therapy

Research from U.N Das and co-authors provides new data about glioma therapy

Published in Cancer Weekly, August 21st, 2007

Fresh data on glioma are presented in the report "Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies." According to recent research from the United States, "Gamma-linolenic acid (GLA) induced apoptosis of tumor cells without harming normal cells. Both cyclo-oxygenase (COX) and lipoxygenase (LO) inhibitors did not inhibit the selective tumoricidal action of GLA in some, but not all, tumor cells suggesting that GLA by itself is active."

"In contrast, anti-oxidants such as vitamin E blocked the tumoricidal action of GLA. GLA-treated tumor but not normal cells produced a 2-3-fold increase in free radicals and lipid peroxides....

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