Hepatocellular Cancer Therapy
Research on hepatocellular cancer therapy published by scientists at St. Marianna University, Department of Pharmacology
Published in Cancer Weekly, August 28th, 2007
Fresh data on hepatocellular cancer are presented in the report "Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis." According to a study from Kanagawa, Japan, "The topoisomerase I inhibitor irinotecan is widely used in anticancer therapy, although the detailed mechanism is still unclear. We investigated the apoptotic mechanisms of irinotecan in human hepatocellular carcinoma (HCC) cell lines (Huh7)."
"SN-38 caused a significant decrease in cell proliferation and induced apoptosis in Huh7 cells and HepG2 cells. SN-38 significantly increased the expression of p53 protein and its phosphorylation at Ser(15) in the...
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Source: Cancer Weekly (2007-08-28)
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