Lymphoma
Scientists at St. Jude Children's Research Hospital, Department of Biochemistry report research in lymphoma
Published in Cancer Weekly, August 28th, 2007
Fresh data on lymphoma are presented in the report "Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. Myc oncoproteins are commonly activated in malignancies and are sufficient to provoke many types of cancer. However, the critical mechanisms by which Myc contributes to malignant transformation are not clear," scientists writing in the journal Molecular Cancer Research report.
"DNA damage seems to be an important initiating event in tumorigenesis. Here, we show that although Myc does not directly induce double-stranded DNA breaks, it does augment activation of the Atm/p53 DNA damage response pathway, suggesting that...
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Source: Cancer Weekly (2007-08-28)
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