Molecular Therapies
New findings from INSERM in the area of molecular therapies published
Published in Cancer Weekly, August 28th, 2007
Data detailed in "Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide" have been presented. "We examined the role of sphingosine kinase-1 (SphK1), a critical regulator of the ceramide/sphingosine 1-phosphate (S1P) biostat, in the regulation of death and survival of SH-SY5Y neuroblastoma cells in response to amyloid beta (Abeta) peptide (25-35). Upon incubation with Abeta, SH-SY5Y cells displayed a marked down-regulation of SphK1 activity coupled with an increase in the ceramide/S1P ratio followed by cell death," investigators in Toulouse, France report.
"This mechanism was redox-sensitive; N-acetylcysteine...
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Source: Cancer Weekly (2007-08-28)
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