Apoptosis

Study results from Keio University provide new insights into apoptosis

Published in Cancer Weekly, August 28th, 2007

According to a study from Tokyo, Japan, "Several anti-cancer agents are derivative from natural products and microorganisms. The dolastatins are natural peptides derived from the marine mollusc Dolabella auricularia, which have recently been reported as an anticancer agent."

"Dolastatin 10 and 15 are small peptides; most preclinical studies have used dolastatin 10. It has been reported that dolastatins have cytotoxic activity by inhibiting microtubule assembly, and several clinical studies have already begun for solid tumors. However, the effects of dolastatin 15 against hematological malignancies such as myeloma cells have never been reported. We demonstrate here for...

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Source: Cancer Weekly (2007-08-28)

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