Cancer
Study results from Spanish National Cancer Center in the area of cancer published
Published in Cancer Weekly, September 4th, 2007
Fresh data on cancer are presented in the report "MGMT hypermethylation: a prognostic foe, a predictive friend." According to a study from Madrid, Spain, "Alkylation of DNA at the O(6)-position of guanine is one of the most critical events leading to mutation, cancer, and cell death. O(6)-alkylguanine-DNA alkyltransferase (AGT), also known as O(6)-methylguanine-DNA methyltransferase (MGMT), is the DNA repair protein responsible for removing alkylation adducts from the O(6)-position of guanine in DNA."
"The promoter CpG island hypermethylation-associated gene silencing of MGMT is associated with a wide spectrum of human tumors. This epigenetic inactivation of MGMT has...
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Source: Cancer Weekly (2007-09-04)
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