B-Cell Lymphoma Prevention
New findings from State University of New York describe advances in B-cell lymphoma prevention
Published in Cancer Weekly, September 4th, 2007
A report, "Augmented antitumor activity against B-cell lymphoma by a combination of monoclonal antibodies targeting TRAIL-R1 and CD20," is newly published data in Clinical Cancer Research. According to recent research from the United States, "Mapatumumab and lexatumumab are fully humanized, high-affinity immunoglobulin G(1 lambda) monoclonal antibodies (mAb) that target/activate the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2), respectively, triggering the extrinsic apoptotic pathway. Theoretically, synergistic antitumor activity should be observed by combining TRAIL-R mAbs with agents (e.g., rituximab) that activate...
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Source: Cancer Weekly (2007-09-04)
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