Follicular Lymphoma Genetics
Researchers from University of Michigan, Department of Internal Medicine detail findings in follicular lymphoma genetics
Published in Cancer Weekly, September 11th, 2007
A new study, "Comprehensive analysis of copy number and allele status identifies multiple chromosome defects underlying follicular lymphoma pathogenesis," is now available. According to a study from the United States, "Follicular lymphoma (FL) constitutes the second most common non-Hodgkin's lymphoma in the Western world. The clinical course is variable and only in part explained by known tumor-intrinsic or -extrinsic factors."
"FL carries the hallmark chromosomal translocation t(14;18), deregulating the expression of Bcl-2, but this is not sufficient to explain either FL biology or clinical behavior. We have employed high-density genomic profiling technology using the...
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Source: Cancer Weekly (2007-09-11)
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