Osteosarcoma

Study results from University of Sao Paulo update understanding of osteosarcoma

Published in Cancer Weekly, September 11th, 2007

"Osteosarcoma (CS) is a primary malignant tumor of bone. Despite the successful use of multiple chemotherapeutic agents in the treatment of OS, more than 30% of OS tumors remain resistant to treatment," scientists writing in the Journal of Orthopaedic Research report.

"Elucidation of cellular resistance mechanisms may lead to better treatments for cancer patients. In this study, we used the low-density expression cDNA array, GEArray Q Series Human Cancer Drug Resistance and Metabolism Gene Array to screen genes related to drug resistance in 15 OS tumors. Expression patterns of the MPV gene were validated by real time PCR on 45 OS patient tumor samples and...

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Source: Cancer Weekly (2007-09-11)

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