Monoclonal Antibodies
Researchers from National Cancer Center Hospital report details of new studies and findings in the area of monoclonal antibodies
Published in Cancer Weekly, September 25th, 2007
New research, "Antibody-dependent cellular cytotoxicity of cetuximab against tumor cells with wild-type or mutant epidermal growth factor receptor," is the subject of a report. According to recent research published in the journal Cancer Science, "Cetuximab (Erbitux, IMC-C225) is a monoclonal antibody targeted to the epidermal growth factor receptor (EGFR). To clarify the mode of antitumor action of cetuximab, we examined antibody-dependent cellular cytotoxicity (ADCC) activity against several tumor cell lines expressing wild-type or mutant EGFR."
"ADCC activity and complement-dependent cytolysis activity were analyzed using the CytoTox 96 assay. ADCC activities...
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Source: Cancer Weekly (2007-09-25)
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