Breast Cancer

Researchers from Erasmus University describe findings in breast cancer

Published in Cancer Weekly, October 2nd, 2007

According to a study from Netherlands, "TIMP-1 protein is a prognostic factor for recurrence-free and overall survival (OS) time in breast cancer. We evaluated the prognostic value of TIMP1 mRNA and a novel TIMP1 mRNA splice variant in 1301 primary breast cancer patients."

"We measured mRNA transcripts of full-length TIMP1 (TIMP1-v1) and the novel splice variant lacking exon 2 (TIMP1-v2) by use of real-time RT-PCR in frozen primary tumor samples. Transcript concentrations are correlated with histomorphological and biological factors, TIMP-1 protein, and distant metastasisfree survival (MFS) and OS time. TIMP1-v1 and TIMP1-v2 alone were not informative with respect to...

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Source: Cancer Weekly (2007-10-02)

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