Published in Cancer Weekly, October 2nd, 2007
Study 1: New research, "Osteopontin gene expression determines spontaneous metastatic performance of orthotopic human breast cancer xenografts," is the subject of a report. "A major problem in the therapeutic management of cancer is the growth of metastases in distant organs, but the genes orchestrating the process need to be identified for the rational design of new treatment. Here, we provide decisive experimental evidence demonstrating the causal involvement of a specific gene, osteopontin (OPN), in the pathogenesis of metastasis by human breast cancer cells and implicating some of...
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