Gastric Cancer

University of Nottingham, Wolfson Digestive Diseases Center publishes research in gastric cancer

Published in Cancer Weekly, October 9th, 2007

A new study, 'A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer,' is now available. According to a study from Nottingham, the United Kingdom, "Helicobacter pylori is the main cause of peptic ulceration and gastric adenocarcinoma. The vacuolating cytotoxin gene, vacA, is a major determinant of virulence."

"Two naturally polymorphic sites in vacA, the signal region and midregion, are well-characterized determinants of toxicity and markers of pathogenesis. The aim of this study was to characterize a new vacA polymorphic site, the intermediate (i) region. METHODs: The vacA i-region was identified...

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Source: Cancer Weekly (2007-10-09)

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