Nasopharyngeal Carcinoma

Research from Y.P. Mei and co-researchers yields new findings on nasopharyngeal carcinoma

Published in Cancer Weekly, October 23rd, 2007

According to a study from Guangzhou, People's Republic of China, "'The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC). In this study, we investigated that the effect of silencing LMP1 on cell cycle distribution and chemosensitivity in EBV-positive naso pharyngeal carcinoma C666-1 cells."

"Silencing of LMP1 by specific siRNA induced G(1) arrest in C666-1 cells. The protein expression of CDK4 and cyclin D1 decreased and P27 was upregulated following LMP1 knockdown. Phosphorylation of AKT and its downstream targets IkB, FKHR was inhibited by LMP1 siRNA. The chemosensitivity of C666-1 cells to bleomycin...

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Source: Cancer Weekly (2007-10-23)

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