Published in Cancer Weekly, October 23rd, 2007
"Silencing of LMP1 by specific siRNA induced G(1) arrest in C666-1 cells. The protein expression of CDK4 and cyclin D1 decreased and P27 was upregulated following LMP1 knockdown. Phosphorylation of AKT and its downstream targets IkB, FKHR was inhibited by LMP1 siRNA. The chemosensitivity of C666-1 cells to bleomycin...
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