Published in Cancer Weekly, November 6th, 2007
"This study assessed the effects of overexpression of IGFBP-4 on the development of cancer in vivo. Method Nude mice were subcutaneously inoculated with HT-29 colorectal cancer cells (3 x 10(6)). When the tumour became visible (1 week after inoculation), animals received either 150 mu g of mammalian expression vector containing IGFBP-4 cDNA or vector alone (n = 6 each) by peritumoural injection. Tumour size was measured during the growth. After 3 weeks of IGFBP-4...
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