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Cancer Gene Therapy

Studies from University College reveal new findings on cancer gene therapy

Published in Cancer Weekly, November 6th, 2007

"Objective Insulin-like growth factor (IGF)-I induces proliferation of transformed cells. Its binding proteins (IGFBP) are involved in local regulation of IGF," scientists in London, the United Kingdom report.

"This study assessed the effects of overexpression of IGFBP-4 on the development of cancer in vivo. Method Nude mice were subcutaneously inoculated with HT-29 colorectal cancer cells (3 x 10(6)). When the tumour became visible (1 week after inoculation), animals received either 150 mu g of mammalian expression vector containing IGFBP-4 cDNA or vector alone (n = 6 each) by peritumoural injection. Tumour size was measured during the growth. After 3 weeks of IGFBP-4...

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