Neuroblastoma
New findings from University of Granada, Medical Department in the area of neuroblastoma described
Published in Cancer Weekly, November 13th, 2007
"We evaluated the effect of haloperidol (HP) and its metabolites on [H-3](+)-pentazocine binding to sigma(1) receptors in SH-SY5Y human neuroblastorna cells and guinea pig brain P-1, P-2 and P-3 subcellular fractions. Three days after a single i.p. injection in guinea pigs of HP (but not of other a, antagonists or (-)-sulpiride), [H-3](+)-pentazocine binding to brain membranes was markedly decreased," researchers in Granada, Spain report.
"Recovery of a, receptor density to steady state after HP-induced inactivation required more than 30 days. HP-metabolite 11 (reduced HP, 4-(4-chlorophenyl)-alpha-(4-fluorophenyl)-4-hydroxy-1 -piperidinebutanol), but not HP-metabolite I...
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Source: Cancer Weekly (2007-11-13)
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