Kaposi Sarcoma Immunology
Research from Charles University, Institute of Immunology and Microbiology in the area of Kaposi sarcoma immunology published
Published in Cancer Weekly, November 20th, 2007
Data detailed in 'Stimulation of c-Myc transcriptional activity by vIRF-3 of Kaposi sarcoma-associated herpesvirus' have been presented. According to a study from Prague, Czech Republic, "Kaposi sarcoma-associated herpesvirus is associated with two lymphoproliferative disorders, primary effusion lymphoma (PEL) and Castleman disease. In PEL, Kaposi sarcoma-associated herpesvirus is present in a latent form expressing only few viral genes."
"Among them is a viral homologue of cellular interferon regulatory factors, vIRF-3. To study the role of vIRF-3 in PEL lymphomagenesis, we analyzed the interaction of vIRF-3 with cellular proteins. Using yeast two-hybrid screen, we...
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Source: Cancer Weekly (2007-11-20)
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