Acute Lymphoblastic Leukemia
New acute lymphoblastic leukemia in children study results from Tohoku University, Department of Pediatrics described
Published in Cancer Weekly, November 27th, 2007
Investigators publish new data in the report 'PTHrP-independent hypercalcemia with increased proinflammatory cytokines and bone resorption in two children with CD19-negative precursor B acute lymphoblastic leukemia.' "Hypercalcemia in childhood acute lymphoblastic leukemia (ALL) is rare and occasionally associated with parathyroid hormone-related protein (PTHrP). However, the pathogenesis of PTHrP-independent hypercalcemia remains unclear," scientists in Sendai, Japan report.
"We report two children with precursor B ALL who had marked hypercalcemia (15.8 and 16.6 mg/dl, respectively) and disseminated osteolysis. Serum tumor necrosis factor-alpha (TNF-alpha) and IL-6...
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Source: Cancer Weekly (2007-11-27)
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