Carcinoma

Research in the area of carcinoma reported from D. Nonclercq and colleagues

Published in Cancer Weekly, December 4th, 2007

According to recent research published in the Journal of Molecular Endocrinology, "We used the Crm1 inhibitor leptomycin B (LMB) to examine a possible involvement of nuclear export in estrogen receptor alpha, (ER) level and function in MCF-7 breast carcinoma cells. As revealed by immunofluorescence microscopy and western blotting with anti-ER antibodies, LMB produced an accumulation of ER in cell nuclei."

"LMB also partly abrogated ER elimination resulting from Hsp90 disruption and 17 beta-estradiol (E2)-induced ER downregulation. By contrast, it was ineffective on ER downregulation caused by the pure anti-estrogen fulvestrant. Finally, LMB inhibited E-2-induced...

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Source: Cancer Weekly (2007-12-04)

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