Angiosarcoma Genetics
New angiosarcoma genetics findings from Showa University described
Published in Cancer Weekly, December 4th, 2007
A report, 'Mutation of the PTEN gene in a human hepatic angiosarcoma,' is newly published data in Cancer Genetics and Cytogenetics. "The phosphatase and tensin homolog (mutated in multiple advanced cancers 1) gene, or PTEN, encodes a lipid phosphatase that contains a PTPase domain and a C2 domain and plays a role as a tumor suppressor that negatively regulates the cell-survival signaling pathway initiated by phosphatidylinositol 3-kinase (PI3K). The PTEN protein inhibits angiogenesis, and somatic mutations of the PTEN gene are involved in canine hemangiosarcoma," scientists in Yokohama, Japan report.
"We screened for mutations of the PTEN gene in two patients...
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Source: Cancer Weekly (2007-12-04)
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