Cancer Gene Therapy
Research from University of Navarra in the area of cancer gene therapy described
Published in Cancer Weekly, December 4th, 2007
"The preclinical evaluation of toxicity and antitumor effect of conditionally replicative ( oncolytic) adenoviruses is hampered by the inability of human adenoviruses to replicate efficiently in murine cells. The Syrian golden hamster ( Mesocricetus auratus) has been suggested as a permissive animal for adenoviral replication, and cancer cell lines derived from various hamster tumors are available," investigators in Pamplona, Spain report.
"We provide evidence that wild-type adenovirus type 5 is able to infect and replicate in the pancreatic cancer cell lines HaP-T1 and H2T both in vitro and in vivo. Determination of cytopathic effect, viral spread, progeny production,...
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Source: Cancer Weekly (2007-12-04)
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