Cancer Vaccines

St. Jude Finds Molecule That Could Improve Cancer Vaccine and Therapy for Other Diseases

Published in Cancer Weekly, December 4th, 2007

Investigators at St. Jude Children's Research Hospital have discovered a new signaling molecule that prevents immune responses from running amok and damaging the body. The finding could lead to the development of new treatments for cancer, using vaccines; for autoimmune diseases, such as Type 1 diabetes; and for inflammatory diseases, such as inflammatory bowel disease and asthma.

The St. Jude team discovered that specialized immune lymphocytes called regulatory T cells release a protein complex composed of two proteins called Ebi3 and Il12a. This complex acts like a brake on the activity of the aggressive immune cells called effector T lymphocytes. The discovery is...

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Source: Cancer Weekly (2007-12-04)

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