Breast Cancer

Researchers at Ohio State University target breast cancer

Published in Cancer Weekly, December 4th, 2007

"The sodium/iodide symporter (NIS) is a membrane glycoprotein mediating active iodide uptake in the thyroid gland and is the molecular basis for radioiodide imaging and therapeutic ablation of thyroid carcinomas. NIS is expressed in the lactating mammary gland and in many human breast tumors, raising interest in similar use for diagnosis and treatment," scientists in the United States report.

"However, few human breast tumors have clinically evident iodide uptake ability. We previously identified PI3K signaling as important in NIS upregulation in transgenic mouse models of breast cancer, and the PI3K pathway is commonly activated in human breast cancer NIS expression,...

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Source: Cancer Weekly (2007-12-04)

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