Cancer Weekly
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Cancer Gene Therapy
Research from C.F. Xia and co-authors in the area of cancer gene therapy published
December 18th, 2007
Investigators publish new data in the report 'Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology.' "The effective delivery of short interfering RNA (siRNA) to brain following intravenous administration requires the development of a delivery system for transport of the siRNA across the brain capillary endothelial wall, which forms the blood-brain barrier in vivo. siRNA was delivered to brain in vivo with the combined use of a receptor-specific monoclonal antibody delivery system, and avidin-biotin technology," scientists writing in the journal Pharmaceutical Research report. "The siRNA was mono-biotinylated on either terminus of...
Source: Cancer Weekly (2007-12-18)
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