Cancer Weekly
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Gene Therapy
Research on gene therapy described by scientists at Vanderbilt University, Vanderbilt-Ingram Comprehensive Cancer Center
December 18th, 2007
Data detailed in 'Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL' have been presented. "Lipid peroxidation is a consequence of both normal physiology and oxidative stress that generates various reactive metabolites, a principal end product being 4-hydroxynonenal (HNE). As a diffusible electrophile, HNE reacts extensively with cellular nucleophiles," scientists writing in the Journal of Biological Chemistry report. "Consequently, HNE alters cellular signaling and activates the intrinsic apoptotic cascade. We have previously demonstrated that in addition to promoting...
Source: Cancer Weekly (2007-12-18)
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