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Leukemia Gene Therapy
Scientists at Medical School target leukemia gene therapy
December 18th, 2007
Scientists discuss in 'HIV vector-mediated targeted suicide gene therapy for adult T-cell leukemia' new findings in leukemia. According to a study from Tokyo, Japan, "We investigated the potential efficacy of treating adult T-cell leukemia (ATL) using a gene therapeutic approach involving the use of a herpes simplex virus-thymidine kinase (HSV-TK)-mediated suicide system. Human immunodeficiency virus (HIV)-based vectors containing the HSV-TK gene were constructed to achieve targeted gene transfer into CD4-positive ATL cells, after which the transduced cells were selectively killed by treatment with ganciclovir (GCV)." "To examine the utility of HIV vectors in vivo,...
Source: Cancer Weekly (2007-12-18)
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