Life Sciences
Research from Harvard University in the area of life sciences published
Published in Cancer Weekly, December 18th, 2007
Research findings, 'The natural product avrainvillamide binds to the oncoprotein nucleophosmin,' are discussed in a new report. "Here we present evidence that (+)-avrainvillamide, a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Among other effects, nucleophosmin is known to regulate the tumor suppressor protein p53," scientists in the United States report.
"A synthetic biotin-avrainvillamide conjugate, nearly equipotent to the natural product in inhibiting the growth of cultured T-47D cells, was used for affinity-isolation of a...
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Source: Cancer Weekly (2007-12-18)
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