Cancer Weekly
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Breast Cancer
Researchers from McGill University report on findings in breast cancer
December 18th, 2007
According to a study from Montreal, Canada, "Tumor cells utilize glucose as a primary energy source and require ongoing lipid biosynthesis for growth. Expression of DecR1, an auxiliary enzyme in the fatty acid P-oxidation pathway, is significantly diminished in numerous spontaneous mammary tumor models and in primary human breast cancer." "Moreover, ectopic expression of DecR1 in ErbB2/Neu-induced mammary tumor cells is sufficient to reduce levels of ErbB2/Neu expression and impair mammary tumor outgrowth. This correlates with a decreased proliferative index and reduced rates of de novo fatty acid synthesis in DecR1-expressing breast cancer cells. Although DecR1...
Source: Cancer Weekly (2007-12-18)
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