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Protease

Research reports from Tri-Service General Hospital provide new insights into protease

Published in Cancer Weekly, December 25th, 2007

According to a study from Neihu, Taiwan, "Matriptase, a type II transmembrane serine protease, is distributed in almost all normal human epithelium. Several studies have demonstrated that matriptase expression, is correlated with tumor progression in epithelium-derived cancer cells."

"Mast cells, which originate from pluripotent hematopoietic cells in the bone marrow, can produce and store almost cellular-specific neutral serine proteases, such as tryptase and chymase, and are functionally involved in both the immediate hypersensitivity response and anaphylactic shock. Mast cells are significantly increased in several neoplasms, indicating that they most likely play a...

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