Soft Tissue Sarcoma

Investigators at Kanagawa University target soft tissue sarcoma

Published in Cancer Weekly, December 25th, 2007

According to recent research from Kanazawa, Japan, "Caffeine, which has a DNA-repair inhibiting effect, enhances the cytocidal effects of anticancer drugs and radiation. The present study was performed to assess the efficacy of caffeine-potentiated chemotherapy for high-grade soft tissue sarcoma (STS)."

"A non-randomised prospective clinical trial was initiated for 90 patients with non-metastatic (stages H and III) or metastatic (stage M STS. Following doxorubicin or ifosfamide combined with caffeine, with or without radiotherapy, 88 patients were treated surgically. A radiographic and histological response to chemotherapy was assessed. Local-recurrence free,...

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Source: Cancer Weekly (2007-12-25)

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