Hepatitis B Virus
New hepatitis B virus study findings have been reported by researchers at Seoul National University
Published in Cancer Weekly, January 1st, 2008
According to a study from Seoul, South Korea, "Nuclear factor (NF)-kappa B is important for immune responses and cell survival; however, abnormal activation of NF-kappa B is linked with many types of diseases, including hepatocellular carcinoma (HCC). Our previous report indicated that hepatitis B virus (HBV) induces NF-kappa B activation through NF-kappa B-inducing kinase (NIK), and this can be blocked specifically by interferon (IFN)-gamma."
"In the present study, we report that HBV expression in HCC cell lines induces drug resistance against 5-fluorouracil (5-FU). This drug resistance was abolished by inhibition of NF-kappa B activation through small interfering...
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Source: Cancer Weekly (2008-01-01)
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