Cancer Gene Therapy

Studies from Louisiana State University have provided new information about cancer gene therapy

Published in Cancer Weekly, January 8th, 2008

According to recent research published in the Journal of Surgical Research, "Eukaryotic initiation factor 4E (eIF4E) facilitates the translation of mRNAs with long 5' untranslated regions and thus regulates protein synthesis. This protein has been found in elevated quantities in breast, colon, and head and neck cancers."

"To exploit this dysfunction, the 619 base pair 5' untranslated regions of fibroblast growth factor-2 was spliced upstream of the herpes simplex virus thymidine kinase gene in an adenovirus vector (Ad-HSV-UTK), with the expectation that TK will be expressed in cells that overexpress eIF4E and, thus, render these cells susceptible to ganciclovir....

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Source: Cancer Weekly (2008-01-08)

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