Cancer Vaccines

Research from Duke University in the area of cancer vaccines published

Published in Cancer Weekly, January 8th, 2008

"The HER2-inhibiting antibody trastuzumab, in combination with chemotherapy, significantly improves survival of women with resected, HER2-overexpressing breast cancers, but is associated with toxicities including a risk of cardiomyopathy. Additionally, the beneficial effect of trastuzumab is expected to decrease once the drug is discontinued," scientists in the United States report.

"We proposed to address these concerns by using cancer vaccines to stimulate HER2 intracellular domain (ICD)-specific T cell and antibody responses. Subjects with stage II (>= 6 + LN), III, or stage IV breast cancerwith > 50% HER2 overexpressing tumor cells who were disease-free after...

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Source: Cancer Weekly (2008-01-08)

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