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Leukemia Gene Therapy
University of Freiburg describes research in leukemia gene therapy
January 15th, 2008
Fresh data on leukemia are presented in the report 'Vectors selected from adeno-associated viral display peptide libraries for leukemia cell-targeted cytotoxic gene therapy.' According to recent research from Freiburg, Germany, "For acute myeloid leukemia (AML), gene therapy may be used to treat patients refractory to conventional chemotherapy. However, availability of vectors sufficiently and specifically transducing this cell type is very limited." "Here we report the selection of capsid-modified adeno-associated viral (AAV) vectors targeting Kasumi-1 AML cells by screening random AAV displayed peptide libraries. The peptide inserts of the enriched capsid mutants...
Source: Cancer Weekly (2008-01-15)
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