Cancer Weekly
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Adenoma
Research from Washington University, Medical Department has provided new information about adenoma
January 15th, 2008
According to recent research from the United States, "dWe have previously identified murine lung adenoma susceptibility I (Las1) as the pulmonary adenoma susceptibility 1 candidate gene. Last has two natural alleles, Las1-A/J and Las1-B6." "Las1 encodes an 85-kDa protein with uncharacterized biological function. In the present study, we report that Last is an unstable protein and the rapid destruction of Last depends on the ubiquitin-proteasome pathway. Last is a new microtubule-binding protein and Last associated with tubulin is not ubiquitinated. We further show that Las1-A/J is a more stable protein than Las1-B6. Last is expressed in the G(2) phase of the cell cycle...
Source: Cancer Weekly (2008-01-15)
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