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Alzheimer Disease
Findings in Alzheimer disease reported from Johns Hopkins University, Medical Department
January 15th, 2008
According to recent research from the United States, "Although gamma-secretase is recognized as a therapeutic target for Alzheimer's disease, side effects associated with strong inhibition of this aspartyl protease raised serious concerns regarding this therapeutic strategy. However, it is not known whether moderate inhibition of this enzyme will allow dissociation of beneficial effects in the CNS from mechanism-based toxicities in the periphery." "We tested this possibility by using a series of mice with genetic reduction of gamma-secretase ( levels ranging from 25 to 64% of control mice). Here, we document that even 30% reduction of gamma-secretase can effectively...
Source: Cancer Weekly (2008-01-15)
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