Retinoblastoma

Research in the area of retinoblastoma reported from A. Albini and colleagues

Published in Cancer Weekly, January 15th, 2008

According to recent research from Milan, Italy, "Ocular tumors such as retinoblastoma and uveal melanoma have devastating effects on vision. Patients with uveal melanoma also have low 5-year survival rates, thus new therapeutic modalities are necessary."

"As both retinoblastoma and uveal melanoma are highly vascular, we tested application of a gene transduction approach with a potent TH1 cytokine also endowed with strong anti-angiogenic activity, Interleukin-12 (IL-12). Gene transfer into murine 99E1 uveal melanoma-like cells, while having no effects on growth in vitro, essentially blocked subcutaneous tumor growth in vivo without evident signs of toxicity. Orthotopic...

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Source: Cancer Weekly (2008-01-15)

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