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Cancer Gene Therapy
Study data from G.I. Bauerschmitz et al provide new insights into cancer gene therapy
January 15th, 2008
According to recent research from Dusseldorf, Germany, "Cancer gene therapy is a promising novel approach to treat cancers resistant to currently available modalities. Such treatment approaches are based on making use of the molecular differences between normal and tumor cells." "Conditional replicating adenoviruses (CRAds) have proved particularly effective in initial preclinical and clinical studies. Requirements for construction of an effective CRAd are sufficient target cell specificity combined with efficient viral infection and replication. For this reason, we cloned triple-targeted oncolytic viruses with the following modifications: transcriptional targeting is...
Source: Cancer Weekly (2008-01-15)
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